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Drugmakers have brought almost 450 orphan drugs to market and collected rich incentives by doing so. But nearly a third of the medicines aren't new or were repurposed many times for financial gain.

Women often bear a heavier burden at times of crisis. Yet they draw on their inner strength to survive — and thrive. NPR photographed and interviewed 19 women over 3 weeks. Here are their stories.

Russia launched a major air attack early Thursday on Kyiv that included a rare strike on the city center, killing at least 21 people, wounding 48 and damaging European diplomatic offices.

St. Louis might be known for legendary entertainers like Josephine Baker, or star athletes like Yogi Berra, but now there's something else putting the city on the map. It's known as the 'Chess Capital of the World.' Host Michel Martin learns more from St. Louis native and chess National Master, Charles Lawton.

Indeed, the gaming industry is not recession-proof. The financial collapse hit Las Vegas hard, and casino revenues dropped for 22 straight months. The city is now taking steps to claw its way back. In doing so, it may emerge as more than a one-economy town.

It was an intelligence community whistleblower who brought the matter to the attention of Congress. But insiders also recorded objections about what took place within the administration.

The explosion in online holiday shopping means billions of packages need to be delivered — and companies like UPS, FedEx and Amazon are under more pressure than ever.

The top U.S. intelligence officials detailed concerns to the Senate Intelligence Committee on Wednesday, with many questions raised about cyberthreats and espionage targeting U.S. technology.

NPR's Steve Inskeep talks to Biden economic advisor Jared Bernstein about the White House push for a $1.9 trillion COVID-19 relief package, and Republican efforts to scale it down.

Lawmakers in both parties are trying to balance the competing needs of powerful stakeholders and consumers stuck with high bills. Despite progress, many insiders expect work to continue into 2020.